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Off-Target Effects Episode 6: BridgeBio Founder & CEO Neil Kumar discusses the hub and spoke biotech model and trying to build a sustainable business for the long-term
He and Matt talk about portfolio construction, and the dynamics of taking on the right capital structure throughout different phases of a company's lifecycle. Neil shares early learnings from the commercial launch of Attruby, how being a commercial stage company can impact culture, and why he created the early-stage R&D focused sister company Gondola. Plus, discussing talent, intellectual property, and more. Chapters The hub and spoke model - 0:41 Equity structure - 5:43 Putt
1 day ago


Off-Target Effects Episode 5: John Maraganore has been a champion of innovation throughout his career. He discusses the road to success at Alnylam, today's environment, and keeping the U.S. on top
Reflecting on the decades-long journey at Alnylam, John Maraganore describes making it through lean times, and how far oligos and RNAi have come today. Matt asks him about championing true innovation, and what the word 'innovation' even means in today's environment. Plus, his thoughts on China, drug pricing and access, IP, AI ,and more. Chapters Championing innovation - 1:12 Oligos and RNAi today - 5:41 China - 16:20 Me-too and differentiation - 19:11 Drug pricing and access
Apr 9


Off-Target Effects Episode 4: Matt speaks with Philip Ross, one of the most experienced and successful bankers in healthcare, about the M&A landscape and his decision to join Jefferies last year
Philip Ross talks about the outlook for M&A in our industry, and describes the pharma revenue growth demands that will be driving it. He...
Jun 30, 2025


Off-Target Effects Episode 3: Matt speaks with STAT News' Adam Feuerstein about the dynamics of biotech journalism and how it compares to other industries
Adam shares his background of previously covering the tech industry, and compares and contrasts it to covering biotech. He describes his...
May 7, 2025


Off-Target Effects Episode 2: Matt speaks with Avoro Capital's Behzad Aghazadeh about the hot button issues that have been striking the biotech sector
One of the largest and most successful biotech investors, Dr. Aghazadeh is asked about key current events like turnover at FDA, tariffs,...
Apr 10, 2025


Off-Target Effects Episode 1: From SF Healthcare Week, Matt interviews Brad Loncar about M&A and China's potential impact on it
For the first episode of the new video podcast, Matt turns the tables on Brad Loncar and interviews him about his experiences and...
Jan 16, 2025






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