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Seattle based Umoja Biopharma is a pioneer of in vivo CAR-T cell engineering. CEO Andrew Scharenberg describes the technical innovations they have come up with to help make it succeed

blonca9
Dec 11, 2024
1 min read

He describes Umoja's numerous platforms that are aimed at maximizing in vivo success, including the company's proprietary lentiviral vector, a rapamycin based architecture to help the CAR-T cells expand and survive, and a tumor tagging technology that may help in tricky solid tumor settings. Umoja is the first company to have an IND cleared for an in vivo program in the United States.

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CREATE Medicines' platform allows it to program CARs into multiple immune cell types inside the body, and is redosable. While this includes CAR-T, they believe that "in vivo is more than T-cells."

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